Center for Biomarker
Discovery & Translation
Current Projects & Grants
The Center is currently conducting several research projects funded as a Biomarker Developmental Laboratory and a Biomarker Reference Laboratory under the NCI EDRN. Our research also includes technology development and biomarker discovery projects for the Johns Hopkins Proteomic Innovation Center in Heart Failure of NHLBI led by Dr. Jennifer Van Eyk (Cardiology). We are also conducting proteomics research associated with the Programs of Excellence in Glycosciences (PEG) of NHLBI, led by Dr. Gerald Hart (Biological Chemistry).
Proteome characterization center: a genoproteomics pipeline for cancer biomarkers
U24CA160036
NIH/NCI
PI: Chan D, Zhang H, Zhang Z
Role: Co-Principal Investigator
This is a center in Clinical Proteomic Tumor Analysis Consortium (CPTAC). The major goal of this Center is the proteomic characterization of cancer tissues and plasma samples with genomic data to not only verify the genomic alterations at the protein level but also allow for the analysis of unique features that are inherent to proteins including post-translational modification
Prof. Danil W Chen (PI)
Prof. Hui Zhang (PI)
Prof. Zhen Zhang (PI)
David Clark (Post-doc)
Yingwei Hu (Post-doc)
Tung-Shing Mamie Lih (Post-doc)
Felix (Shiyong) Ma (Post-doc)
Lijun Chen (Research Technician)
Mike Schnaubelt (Data Analysis)
Minghui Ao (Research Specialist II)
Clinical and analytical validation of cancer biomarkers
U24CA115102
NIH/NCI
PI: Chan, Daniel
Role: Co-investigator/developmental project leader
Notes: This is a biomarker reference laboratory (BRL) of the Early Detection Research Network (EDRN). The major goal of this project is to conduct analytical and clinical validation studies of biomarkers.
Prof. Danil W Chen (PI)
Prof. Hui Zhang (PI)
Prof. Zhen Zhang (PI)
Naser Hoti
Jing Song
Glycoconjugates and cardiovascular disease
P01HL107153
NIH/NHLBI
PI: Hart, Gerald
Role: Principal Investigator for project #4
Co-Principal Investigator (with Van Eyk) for mass spectrometry core
This is a center of Programs of Excellence in Glycosciences (PEG). The central theme of this center is the roles of both extracellular and intracellular glycoconjugates in the mechanisms protecting the heart or leading to atherosclerosis and cardiomyopathies, culminating in myocardial infarction and heart failure.
HIV
Mechanism and anti-cancer activity of SCFA-hexosamine analogs
R01CA112314
NIH/NCI
PI: Yarema, Kevin
Role: Co-investigator
The goal of the parent grant to this project is to develop novel sugar-based cancer drugs to treat metastatic cancer.
Johns Hopkins proteomic innovation center in heart failure
HHSN268201000032C (N01-HV-00240)
NIH/NHLBI
PI: Van Eyk, Jennifer
Role: Co-investigator
This is a center of NHLBI Proteomics Centers. The goal of this project is to develop and apply innovative mass spectrometry based PTM capture methods in heart failure. In particular, my project will focus on glycoproteome tools in both tissue and blood samples.