Current Projects & Grants
The Center is currently conducting several research projects funded as a Biomarker Developmental Laboratory and a Biomarker Reference Laboratory under the NCI EDRN. Our research also includes technology development and biomarker discovery projects for the Johns Hopkins Proteomic Innovation Center in Heart Failure of NHLBI led by Dr. Jennifer Van Eyk (Cardiology). We are also conducting proteomics research associated with the Programs of Excellence in Glycosciences (PEG) of NHLBI, led by Dr. Gerald Hart (Biological Chemistry).
Proteome characterization center: a genoproteomics pipeline for cancer biomarkers
PI: Chan D, Zhang H, Zhang Z
Role: Co-Principal Investigator
This is a center in Clinical Proteomic Tumor Analysis Consortium (CPTAC). The major goal of this Center is the proteomic characterization of cancer tissues and plasma samples with genomic data to not only verify the genomic alterations at the protein level but also allow for the analysis of unique features that are inherent to proteins including post-translational modification
Clinical and analytical validation of cancer biomarkers
PI: Chan, Daniel
Role: Co-investigator/developmental project leader
Notes: This is a biomarker reference laboratory (BRL) of the Early Detection Research Network (EDRN). The major goal of this project is to conduct analytical and clinical validation studies of biomarkers.
Mechanism and anti-cancer activity of SCFA-hexosamine analogs
PI: Yarema, Kevin
The goal of the parent grant to this project is to develop novel sugar-based cancer drugs to treat metastatic cancer.
Johns Hopkins proteomic innovation center in heart failure
PI: Van Eyk, Jennifer
This is a center of NHLBI Proteomics Centers. The goal of this project is to develop and apply innovative mass spectrometry based PTM capture methods in heart failure. In particular, my project will focus on glycoproteome tools in both tissue and blood samples.